Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) (CAT#: TAB-707)
Recombinant chimeric antibody expressed in CHO binding to human CAIX. Girentuximab is a chimeric monoclonal antibody designed for the treatment of renal cell carcinoma.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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IHC
Figure 4 Immunohistochemical analyses of vital tumor specimens from different groups.
Neoadjuvant treatment with sorafenib resulted in enhanced necrosis (hematoxylin and eosin) and decreased vessel density (CD31) but had no effect on CAIX expression.
Muselaers, C. H., Stillebroer, A. B., Desar, I. M., Boers-Sonderen, M. J., van Herpen, C. M., de Weijert, M. C.,... & Mulders, P. F. (2014). Tyrosine kinase inhibitor sorafenib decreases 111In-girentuximab uptake in patients with clear cell renal cell carcinoma. Journal of Nuclear Medicine, 55(2), 242-247.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Chimeric (Human/Mouse)
- Type
- IgG1 - kappa
- Species Reactivity
- Human
- Applications
- WB, FuncS, IF, Neut, ELISA, FC, IP, PK, IHC, Activ
- Trade name
- rencarex
- CAS
- 916138-87-9
- Generic Name
- Girentuximab
- UNII
- 539B57DFJF
- MW
- 146.5 kDa
- Related Disease
- Renal cell carcinoma (RCC)
Product Property
- Purity
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The CA9 antibody has been reported in applications of WB, FuncS, IF, Neut, ELISA, FC, IP, PK, IHC, Activ.
Target
- Alternative Names
- Girentuximab;rencarex;916138-87-9;WX-G250;cG250;CA9;carbonic anhydrase IX;carbonic anhydrase 9;CAIX;carbonic dehydratase;MN;RCC associated protein G250;pMW1;CA-IX;P54/58N;membrane antigen MN;carbonate dehydratase IX;RCC-associated antigen G250;RCC-associa
- Gene ID
- 768
- UniProt ID
- Q16790
Related Resources
Please refer to Girentuximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Girentuximab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Girentuximab"
Afuco™ Anti-CA9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H43)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Chimeric antibody to Human CA9.
DrugMonitor™ Anti-Girentuximab Antibody (VS-1224-YC521)Girentuximab is a chimeric (mouse/human) monoclonal antibody targeting carbonic anhydrase IX, expressed in 95% of clear cell renal cell carcinomas (RCC). The DrugMonitor™ Anti-Girentuximab Antibody (VS-1224-YC521) is an anti-drug antibody (ADA) against Girentuximab. This drug-based antibody is raised in mice immunized with the Girentuximab. The anti-Girentuximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Girentuximab in samples.
See other products for "CA9"
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H43 | Anti-Human CA9 Recombinant Antibody (TAB-H43) | ELISA, IP, IF, Inhib | IgG1 - kappa |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-707, RRID: AB_3111986)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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